Minimal Residual Disease in Hematological Malignancies

Minimal residual disease in hematological malignancies.

Accessible online at: www.karger.com/aha Do you prefer quality to quantity? This question has been asked for many years. It is well known that mathematics is the science of pure quantity but what about medicine? For many years, counting cells and identifying them by microscopic inspection have determined the number of normal or abnormal cells in hematological and nonhematological malignancies. ...

Status of minimal residual disease testing in childhood haematological malignancies.

In children with acute leukaemia, measurements of minimal residual disease (MRD) provide unique information on treatment response and have become a crucial component of contemporary treatment protocols. In acute lymphoblastic leukaemia (ALL), the most useful MRD assays are based on polymerase chain reaction (PCR) amplification of antigen-receptor genes, and on flow cytometric detection of abnor...

Minimal residual disease in melanoma.

A number of specific genes encoding for melanosomal proteins are selectively expressed in melanocytes and melanomas. For detection of circulating melanoma cells, the expression of the tyrosinase gene is most widely used. Several cohorts of melanoma patients from single institutions have been analyzed by various research groups for the presence of circulating melanoma cells in all stages of dise...

Evaluation Of Background Prediction For Variant Detection In A Clinical Context: Towards Improved Ngs Monitoring Of Minimal Residual Disease In Hematological Malignancies

Minimal residual disease monitoring: the new standard for treatment evaluation of haematological malignancies?

Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. Current treatment protocols for haematological malignancies allow most patients to obtain some form of MRD state, but cure seldom follows and in most cases fatal relapses occur sooner or later, leaving a bitter i...